The mechanism of action of organophosphorus pesticides

Inhibit the activity of acetylcholinesterase, so that acetylcholine cannot be decomposed in time and accumulates, and it continuously binds to the receptors on the postsynaptic membrane, causing the sodium ion channel on the postsynaptic membrane to open for a long time, and the sodium ions flood into the membrane for a long time. Time to get excited. The symptoms of poisoning are ataxia, hyperexcitability, convulsions and death. Organophosphorus directly acts on the "enzyme" that decomposes neurotransmitters, and has a fast insecticidal speed, and its insecticidal has no selectivity and a wide insecticidal spectrum.